METAINTER is a tool to perform
meta-analysis of summary statistics obtained from a series of related studies.
The special feature of METAINTER is the ability to meta-analyze the results of
multiple linear and logistic regression models, broadly used in genome-wide
association studies (GWAS). The tool assumes that a unique pre-defined model is
used in multiple studies to test for association of SNP tuples with a
particular phenotype. SNPs coding and parameters coding in regression models have
to follow the standards specified in [H.J. Cordell, D.G. Clayton, 2002], see also Manual.
results of the individual studies have to be provided in tabulated format.
METAINTER supports the output format of the genetic interaction analysis
software INTERSNP, as well as any freely defined format.
main meta-analysis method implemented in METAINTER is
suggested in [B.J. Becker, M.-J. Wu,
2007]. MSRS requires, in addition to model parameters estimates and their
standard error, the availability of the covariance matrix. The covariance
matrix of model parameters is provided, for instance, by INTERSNP tool. We note that in case of tests with just one parameter, MSRS is
equivalent to the standard fixed effects meta-analysis method. Within MSRS
framework, METAINTER can be used to test the homogeneity of studies results,
and to obtain the common parameter estimates of multiple regression models in
the joint sample.
the covariance matrix of model parameters is not always available, METAINTER
provides three further meta-analysis methods:
Thereby, METAINTER enables
meta-analysis of single-marker association tests, global haplotype tests and
tests for and under gene-gene interaction.
Vaitsiakhovich T, Drichel D, Herold C, Lacour A, Becker T (2015). METAINTER: meta-analysis of multiple regression models in genome-wide association studies. Bioinformatics. 2015 Jan 15;31(2):151-7.